Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model.

Objective: Psoralea corylifolia L. (FP) has received increasing attention due to its potential hepatotoxicity. Methods: In this study, zebrafish were treated with different concentrations of an aqueous extract of FP (AEFP; 40, 50, or 60 µg/mL), and the hepatotoxic effects of tonicity were determined by the mortality rate, liver morphology, fluorescence area and intensity of the liver, biochemical indices, and pathological tissue staining. The mRNA expression of target genes in the bile acid metabolic signaling pathway and lipid metabolic pathway was detected by qPCR, and the mechanism of toxicity was initially investigated. AEFP (50 µg/mL) was administered in combination with FXR or a peroxisome proliferator-activated receptor α (PPARα) agonist/inhibitor to further define the target of toxicity. Results: Experiments on toxic effects showed that, compared with no treatment, AEFP administration resulted in liver atrophy, a smaller fluorescence area in the liver, and a lower fluorescence intensity (p < 0.05); alanine transaminase (ALT), aspartate transaminase (AST), and γ-GT levels were significantly elevated in zebrafish (p < 0.01), and TBA, TBIL, total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were elevated to different degrees (p < 0.05); and increased lipid droplets in the liver appeared as fatty deposits. Molecular biological validation revealed that AEFP inhibited the expression of the FXR gene, causing an increase in the expression of the downstream genes SHP, CYP7A1, CYP8B1, BSEP, MRP2, NTCP, peroxisome proliferator-activated receptor γ (PPARγ), ME-1, SCD-1, lipoprotein lipase (LPL), CPT-1, and CPT-2 and a decrease in the expression of PPARα (p < 0.05). Conclusion: This study demonstrated that tonic acid extracts are hepatotoxic to zebrafish through the inhibition of FXR and PPARα expression, thereby causing bile acid and lipid metabolism disorders.

Structural design of FeCo alloy implanted into N,S co-doped carbon nanotubes via self-catalyzed growth for advanced liquid and flexible all-state-state Zn-air battery.

The introduction of transition bimetallic alloys can effectively improve oxygen reduction reaction (ORR) activity. However, the alloy particles are inclined to dissolve under harsher conditions, resulting in a serious decrease in catalytic activity and stability. Herein, an efficient ORR catalyst, FeCo alloy nanoparticles (NPs) encapsulated in N,S co-doped carbon nanotubes (FeCo10-NSCNTs), was developed through a self-catalyzed growth strategy. Due to the delicate structural design, the N,S co-doped structure can effectively improve the ORR performance by modulating the electronic properties and surface polarity of the carbon substrate, and the randomly connected carbon nanotube structure with large specific surface area can further enhance the adsorption and dissociation of gas molecules, accelerating the kinetics of gas participation in the reaction. Carbon-encapsulated FeCo alloys are beneficial for improving catalytic activity and durability. The FeCo10-NSCNTs displayed excellent ORR activity with a half-wave potential of E1/2 = 0.84 V and robust stability of 13 k cycles. More impressively, the assembled liquid-state Zn-air battery (ZAB) with FeCo10-NSCNTs as the air-electrode delivers an output power density of 146.68 mW cm-2 along with excellent operation durability. The assembled all-solid ZAB has good cyclic stability under 0-180° bending conditions. The synthesized N,S co-doping, carbon nanotubes and FeCo alloys provide important guidance for the construction of cheap non-noble metal-carbon hybrid nanomaterials.

Single-Atom Zinc Sites with Synergetic Multiple Coordination Shells for Electrochemical H2 O2 Production.

Precise manipulation of the coordination environment of single-atom catalysts (SACs), particularly the simultaneous engineering of multiple coordination shells, is crucial to maximize their catalytic performance but remains challenging. Herein, we present a general two-step strategy to fabricate a series of hollow carbon-based SACs featuring asymmetric Zn-N2 O2 moieties simultaneously modulated with S atoms in higher coordination shells of Zn centers (n≥2; designated as Zn-N2 O2 -S). Systematic analyses demonstrate that the synergetic effects between the N2 O2 species in the first coordination shell and the S atoms in higher coordination shells lead to robust discrete Zn sites with the optimal electronic structure for selective O2 reduction to H2 O2 . Remarkably, the Zn-N2 O2 moiety with S atoms in the second coordination shell possesses a nearly ideal Gibbs free energy for the key OOH* intermediate, which favors the formation and desorption of OOH* on Zn sites for H2 O2 generation. Consequently, the Zn-N2 O2 -S SAC exhibits impressive electrochemical H2 O2 production performance with high selectivity of 96 %. Even at a high current density of 80 mA cm-2 in the flow cell, it shows a high H2 O2 production rate of 6.924 mol gcat -1 h-1 with an average Faradaic efficiency of 93.1 %, and excellent durability over 65 h.

Tuberculosis infection following immune checkpoint inhibitor treatment for advanced cancer: a case report and literature review.

Objective: To investigate the clinical features of active tuberculosis (TB) infection due to immune checkpoint inhibitors (ICIs) treatment in patients with advanced cancer. Methods: We report the diagnosis and treatment of a case of pulmonary malignancy (squamous cell carcinoma, cT4N3M0 IIIC), secondary to active TB infection following ICIs therapy. Moreover, we summarize and analyze other related cases collected from the China National Knowledge Infrastructure (CNKI), Wanfang Database, PubMed, the Web of Science, and EMBASE (up to October 2021). Results: A total of 23 patients, including 20 males and 3 females who were aged 49-87 years with a median age of 65 years, were included in the study. Twenty-two patients were diagnosed by Mycobacterium tuberculosis culture or DNA polymerase chain reaction (PCR), while the remaining patient was diagnosed by tuberculin purified protein derivative and pleural biopsy. One case had an interferon-gamma release assay (IGRA) to rule out latent TB infection prior to the application of ICI. Fifteen patients received an anti-tuberculosis regimen. Among the 20 patients with a description of clinical regression, 13 improved and 7 died. Seven of the patients who improved were treated with ICI again and four of them did not experience a recurrence or worsening of TB. The case diagnosed in our hospital also improved after receiving anti-TB treatment after stopping ICI therapy, and continued chemotherapy on the basis of anti-TB treatment, and his condition is relatively stable at present. Conclusion: Due to the lack of specificity of TB infection following ICIs therapy, patients should be followed for fever and respiratory symptoms for 6.3 months after drug administration. It is recommended that IGRA should be performed before ICIs therapy and the development of TB during immunotherapy in patients who are positive in IGRA should be closely monitored. The symptoms of TB in most patients can be improved with ICIs withdrawal and anti-TB treatment, but there is still a need to be alert to the potentially fatal risk of TB.

Synthesis-on-substrate of quantum dot solids.

Perovskite light-emitting diodes (PeLEDs) with an external quantum efficiency exceeding 20% have been achieved in both green and red wavelengths1-5; however, the performance of blue-emitting PeLEDs lags behind6,7. Ultrasmall CsPbBr3 quantum dots are promising candidates with which to realize efficient and stable blue PeLEDs, although it has proven challenging to synthesize a monodispersed population of ultrasmall CsPbBr3 quantum dots, and difficult to retain their solution-phase properties when casting into solid films8. Here we report the direct synthesis-on-substrate of films of suitably coupled, monodispersed, ultrasmall perovskite QDs. We develop ligand structures that enable control over the quantum dots' size, monodispersity and coupling during film-based synthesis. A head group (the side with higher electrostatic potential) on the ligand provides steric hindrance that suppresses the formation of layered perovskites. The tail (the side with lower electrostatic potential) is modified using halide substitution to increase the surface binding affinity, constraining resulting grains to sizes within the quantum confinement regime. The approach achieves high monodispersity (full-width at half-maximum = 23 nm with emission centred at 478 nm) united with strong coupling. We report as a result blue PeLEDs with an external quantum efficiency of 18% at 480 nm and 10% at 465 nm, to our knowledge the highest reported among perovskite blue LEDs by a factor of 1.5 and 2, respectively6,7.

iTRAQ Quantitative Proteomic Analysis of Different Expressed Proteins and Signal Pathways in Bakuchiol-Induced Hepatotoxicity.

Bakuchiol (BAK) is an abundant natural compound. BAK has been reported to have several biological activities such as anticancer, antiaging, anti-inflammatory, and prevention of bone loss. However, it causes hepatotoxicity, the mechanism of which is not known. In this study, we explored the mechanism of BAK hepatotoxicity by treating rats with 52.5 mg/kg and 262.5 mg/kg of BAK, administered continuously for 6 weeks. We examined the liver pathology and biochemical composition of bile to determine toxicity. Mechanisms of BAK hepatotoxicity were analyzed based on relative and absolute quantification (iTRAQ) protein equivalent signatures and validated in vitro using LO2 cells. iTRAQ analysis revealed 281 differentially expressed proteins (DEPs) in liver tissue of the BAK-treated group, of which 215 were upregulated, and 66 were downregulated. GO and KEGG enrichment analysis revealed that bile secretion, lipid metabolism, and cytochrome P450 signaling pathways were enriched in DEPs. Among them, peroxisome proliferator-activated receptor α (PPARα), farnesoid X receptor (FXR), and cholesterol 7α-hydroxylase (CYP7a1) were closely associated with the development and progression of BAK-induced hepatic metabolic dysfunction and abnormal bile metabolism. This study shows that BAK can induce hepatotoxicity through multiple signaling pathways.

Mesoporous N-rich Carbon with Single-Ni Atoms as a Multifunctional Sulfur Host for Li-S Batteries.

Physicochemical confinement and catalytic conversion of lithium polysulfides (LiPSs) are crucial to suppress the shuttle effect and enhance the redox kinetics of lithium-sulfur (Li-S) batteries. In this study, a NH4 Cl-assisted pyrolysis strategy is developed to fabricate highly mesoporous N-rich carbon (designed as NC(p)) featuring thin outer shells and porous inner networks, on which single-Ni atoms are anchored to form an excellent sulfur host (designed as Ni-NC(p)) for Li-S batteries. During pyrolysis, the pyrolytic HCl from confined NH4 Cl within ZIF-8 will in situ etch ZIF-8 to produce rich mesoporous in the carbonized product NC(p). The mesoporous Ni-NC(p) enables favorable electron/ion transfer, high sulfur loading, and effective confinement of LiPSs, while the catalytic effect of single-Ni species enhances the redox kinetics of LiPSs. As a result, the sulfur cathode based on the Ni-NC(p) host delivers obviously improved Li-S battery performance with high specific capacity, good rate capability, and cycling stability.

Integrating Network Pharmacology and In Vivo Model to Investigate the Mechanism of Biheimaer in the Treatment of Functional Dyspepsia.

Objective: Biheimaer (BHM) is a hospital formulation for clinical treatment of dyspepsia and acid reflux, based on Compatibility Theory of Traditional Chinese Medicine. This study anticipated to elucidate the molecular mechanism of BHM against Functional dyspepsia via combined network pharmacology prediction with experimental verification. Methods: Based on network pharmacology, the potential active components and targets of BHM in the treatment of functional dyspepsia were explored by prediction and molecular docking technology. The results of protein-protein interaction analysis, functional annotation, and pathway enrichment analysis further refined the main targets and pathways. The molecular mechanism of BHM improving functional dyspepsia mice induced by L-arginine + atropine was verified on the basis of network pharmacology. Results: In this study, 183 effective compounds were screened from BHM; moreover, 1007 compound-related predicted targets and 156 functional dyspepsia-related targets were found. The results of enrichment analysis and in vivo experiments showed that BHM could regulate intestinal smooth muscle contraction to play a therapeutic role in functional dyspepsia by reducing the expression of NOS3, SERT, TRPV1, and inhibiting the inflammatory cytokine (IL-1ß, TNF-α) to intervene the inflammatory response in mice. Conclusions: This study revealed the molecular biological mechanisms of the Traditional Chinese Medicine formulation of BHM in functional dyspepsia by network pharmacology and experimental verification, meanwhile provided scientific support for subsequent clinical medication.

Recycling of Zinc-Carbon Batteries into MnO/ZnO/C to Fabricate Sustainable Cathodes for Rechargeable Zinc-Ion Batteries.

Acidic zinc-carbon dry batteries have been widely used in life because of their low cost. However, a great quantity of used batteries is discarded as refuse, which not only wastes resources but also leads to environmental contamination. To reuse spent batteries on a large scale, this study concerns a simple, effective, and sustainable strategy to turn them into MnO/ZnO/C composites. After a conventional leaching treatment followed by pyrolysis, the rust cathode materials can be reduced to MnO/ZnO/C. When serving as a rechargeable zinc-ion battery cathode, this electrode provides a maximum reversible capacity of around 362 mAh g-1 MnO ) and a rate capability of 191 mAh g-1 MnO at a high current rate of 1.20 A g-1 . Furthermore, ZnO gradually dissolves in the electrolyte with the increase of discharge cycles, replenishing the Zn2+ content in the electrolyte and further enhancing cycling stability (98.02 % after 500 cycles). The device also exhibits a remarkable energy density of 336.37 Wh kg-1 , low self-discharge rate, and can efficiently power a LED panel. This strategy offers an economical and facile route to convert zinc-carbon battery waste into useful materials for aqueous rechargeable zinc ion batteries.

Novel 3D Printed Vortex-like Flexible Roller-Compacted Triboelectric Nanogenerator for Self-Powered Electrochemical Degradation of Organic Contaminants.

It is an ideal way to use triboelectric nanogenerators (TENGs) to capture energy from the environment for the degradation of organic contaminants in water as a zero-carbon pathway. However, there is an urgent need to further develop TENGs with a simple structure and high output power. Herein, a novel TENG with a vortex-like flexible self-recovery blades of inner stator (denoted as VFR-TENG) is designed and manufactured with the assistance of a fused deposition modeling 3D printing technology. With the rotation of the outer rotor, a facile rotating contact-separation mode is achieved by the alternating arrangement of the flexible self-recovery blades. The contact tightness of the friction layer, a key factor for the transfer of charge density, can be easily adjusted by the thickness and arrangement style of the flexible self-recovery blades. The regulation of material elasticity and rotational frequency on the output characteristics is further investigated based on the special flexible structure. The VFR-TENG exhibits an instantaneous short-circuit current of 350 µA, an open-circuit voltage of 650 V, a transferred charge of 1.1 µC, and an optimum output power density of 4.4 W·m-2. This high-performance VFR-TENG is used for electrochemical degradation systems, which achieves excellent degradation efficiencies of 88.9, 91.7, and 94.1% for methylene blue, methyl orange, and malachite green within 150 min, respectively. This work provides a new idea for the design of flexible self-recovery contact-separation TENGs, which is of great inspiration for the exploitation of TENGs with both the high peak current and high-frequency characteristics for efficient water treatment.

High-Performance Electrochemical Nitrate Reduction to Ammonia under Ambient Conditions Using a FeOOH Nanorod Catalyst.

Electrocatalytic nitrate reduction is promising as an environmentally friendly process to produce high value-added ammonia with simultaneous removal of nitrate, a widespread nitrogen pollutant, for water treatment; however, efficient electrocatalysts with high selectivity are required for ammonia formation. In this work, FeOOH nanorod with intrinsic oxygen vacancy supported on carbon paper (FeOOH/CP) is proposed as a high-performance electrocatalyst for converting nitrate to ammonia at room temperature. When operated in a 0.1 M phosphate-buffered saline (PBS) solution with 0.1 M NaNO3, FeOOH/CP is able to obtain a large NH3 yield of 2419 µg h-1 cm-2 and a surprisingly high Faradic efficiency of 92% with excellent stability. Density functional theory calculation demonstrates that the potential-determining step for nitrate reduction over FeOOH (200) is *NO2H + H+ + e- → *NO + H2O.

Ambient Ammonia Synthesis via Electrochemical Reduction of Nitrate Enabled by NiCo2 O4 Nanowire Array.

NiCo2 O4 nanowire array on carbon cloth (NiCo2 O4 /CC) is proposed as a highly active electrocatalyst for ambient nitrate (NO3 - ) reduction to ammonia (NH3 ). In 0.1 m NaOH solution with 0.1 m NaNO3 , such NiCo2 O4 /CC achieves a high Faradic efficiency of 99.0% and a large NH3 yield up to 973.2 µmol h-1  cm-2 . The superior catalytic activity of NiCo2 O4 comes from its half-metal feature and optimized adsorption energy due to the existence of Ni in the crystal structure. A Zn-NO3 - battery with NiCo2 O4 /CC cathode also shows a record-high battery performance.

Loading Single-Ni Atoms on Assembled Hollow N-Rich Carbon Plates for Efficient CO2 Electroreduction.

The rational design of catalysts' spatial structure is vitally important to boost catalytic performance through exposing the active sites, enhancing the mass transfer, and confining the reactants. Herein, a dual-linker zeolitic tetrazolate framework-engaged strategy is developed to construct assembled hollow plates (AHP) of N-rich carbon (NC), which is loaded with single-Ni atoms to form a highly efficient electrocatalyst (designated as Ni-NC(AHP)). In the carbonization process, the thermally unstable linker (5-aminotetrazole) serves as the self-sacrificial template and the other linker (2-methylimidazole) mainly serves as the carbon and nitrogen source to form hollow NC matrix. The formed Ni-NC(AHP) catalyst possesses enhanced mesoporosity and more available surface area, thus promoting mass transport and affording abundant accessible single-Ni sites. These features contribute to remarkable performance for electrochemical CO2 reduction with exceptionally high selectivity of nearly 100% towards CO in a wide potential range and dramatically enhanced CO partial current density.

Ni2P nanosheet array for high-efficiency electrohydrogenation of nitrite to ammonia at ambient conditions.

Ammonia (NH3) plays an important role in agriculture and industry. The industry-scale production mainly depends on the Haber-Bosch process suffering from issues of environment pollution and energy consumption. Electrochemical reduction can degrade nitrite (NO2-) pollutants in the environment and convert it into more valuable NH3. Here, Ni2P nanosheet array on nickel foam is proposed as a 3D electrocatalyst for high-efficiency electrohydrogenation of NO2- to NH3 under ambient reaction conditions. When tested in 0.1 M phosphate buffer saline with 200 ppm NO2-, such Ni2P/NF is able to obtain a large NH3 yield rate of 2692.2 ± 92.1 µg h-1 cm-2 (3282.9 ± 112.3 µg h-1 mgcat.-1), a high Faradic efficiency of 90.2 ± 3.0%, and selectivity of 87.0 ± 1.7% at -0.3 V versus a reversible hydrogen electrode. After 10 h of electrocatalytic reduction, the conversion rate of NO2- achieves near 100%. The catalytic mechanism is further investigated by density functional theory calculations.

High-Performance Electrochemical NO Reduction into NH3 by MoS2 Nanosheet.

Electrochemical reduction of NO not only offers an attractive alternative to the Haber-Bosch process for ambient NH3 production but mitigates the human-caused unbalance of nitrogen cycle. Herein, we report that MoS2 nanosheet on graphite felt (MoS2 /GF) acts as an efficient and robust 3D electrocatalyst for NO-to-NH3 conversion. In acidic electrolyte, such MoS2 /GF attains a maximal Faradaic efficiency of 76.6 % and a large NH3 yield of up to 99.6 µmol cm-2 h-1 . Using MoS2 nanosheet-loaded carbon paper as the cathode, a proof-of-concept device of Zn-NO battery was assembled to deliver a discharge power density of 1.04 mW cm-2 and an NH3 yield of 411.8 µg h-1 mgcat. -1 . Calculations reveal that the positively charged Mo-edge sites facilitate NO adsorption/activation via an acceptance-donation mechanism and disfavor the binding of protons and the coupling of N-N bond.

Greatly Facilitated Two-Electron Electroreduction of Oxygen into Hydrogen Peroxide over TiO2 by Mn Doping.

Ambient electrochemical oxygen reduction into valuable hydrogen peroxide (H2O2) via a selective two-electron (2e-) pathway is regarded as a sustainable alternative to the industrial anthraquinone process, but it requires advanced electrocatalysts with high activity and selectivity. In this study, we report that Mn-doped TiO2 behaves as an efficient electrocatalyst toward highly selective H2O2 synthesis. This catalyst exhibits markedly enhanced 2e- oxygen reduction reaction performance with a low onset potential of 0.78 V and a high H2O2 selectivity of 92.7%, much superior to the pristine TiO2 (0.64 V, 62.2%). Additionally, it demonstrates a much improved H2O2 yield of up to 205 ppm h-1 with good stability during bulk electrolysis in an H-cell device. The significantly boosted catalytic performance is ascribed to the lattice distortion of Mn-doped TiO2 with a large amount of oxygen vacancies and Ti3+. Density functional theory calculations reveal that Mn dopant improves the electrical conductivity and reduces ΔG*OOH of pristine TiO2, thus giving rise to a highly efficient H2O2 production process.

Ti2O3 Nanoparticles with Ti3+ Sites toward Efficient NH3 Electrosynthesis under Ambient Conditions.

Electrocatalytic nitrogen reduction reaction (NRR) enabled by introducing Ti3+ defect sites into TiO2 through a doping strategy has recently attracted widespread attention. However, the amount of Ti3+ ions is limited due to the low concentration of dopants. Herein, we propose Ti2O3 nanoparticles as a pure Ti3+ system that performs efficiently toward NH3 electrosynthesis under ambient conditions. This work has suggested that Ti3+ ions, as the main catalytically active sites, significantly increase the NRR activity. In an acidic electrolyte, Ti2O3 achieves extraordinary performance with a high NH3 yield and a Faradaic efficiency of 26.01 µg h-1 mg-1 cat. and 9.16%, respectively, which are superior to most titanium-based NRR catalysts recently reported. Significantly, it also demonstrates a stable NH3 yield in five consecutive cycles. Theoretical calculations uncovered that the enhanced electrocatalytic activity of Ti2O3 originated from Ti3+ active sites and significantly lowered the overpotential of the potential-determining step.

Phosphorized CoNi2 S4 Yolk-Shell Spheres for Highly Efficient Hydrogen Production via Water and Urea Electrolysis.

Exploring earth-abundant electrocatalysts with excellent activity, robust stability, and multiple functions is crucial for electrolytic hydrogen generation. Porous phosphorized CoNi2 S4 yolk-shell spheres (P-CoNi2 S4 YSSs) were rationally designed and synthesized by a combined hydrothermal sulfidation and gas-phase phosphorization strategy. Benefiting from the strengthened Ni3+ /Ni2+ couple, enhanced electronic conductivity, and hollow structure, the P-CoNi2 S4 YSSs exhibit excellent activity and durability towards hydrogen/oxygen evolution and urea oxidation reactions in alkaline solution, affording low potentials of -0.135 V, 1.512 V, and 1.306 V (versus reversible hydrogen electrode) at 10 mA cm-2 , respectively. Remarkably, when used as the anode and cathode simultaneously, the P-CoNi2 S4 catalyst merely requires a cell voltage of 1.544 V in water splitting and 1.402 V in urea electrolysis to attain 10 mA cm-2 with excellent durability for 100 h, outperforming most of the reported nickel-based sulfides and even noble-metal-based electrocatalysts. This work promotes the application of sulfides in electrochemical hydrogen production and provides a feasible approach for urea-rich wastewater treatment.

Pore-structure regulation of biomass-derived carbon materials for an enhanced supercapacitor performance.

Herein, we report a dual-porogen synthesis strategy to fabricate a micro-/meso-/macroporous carbon material for supercapacitors from biomass. The hierarchically porous carbon material was produced in a facile way by pyrolyzing C10H14N2Na2O8/KOH (dual-porogen) and walnut peel (biomass carbon source) along with HCl solution etching. Such an admirable dual-porogen strategy opened up the closed pores and broadened the range of pore distribution for the carbon material from 0.55-1.76 nm to 0.59-2.53 nm as the mass ratio of walnut peel and C10H14N2Na2O8 increased from 1 : 0 to 1 : 2, making up for the shortcomings of the narrow microporous distribution caused by the use of potassium hydroxide exclusively. As expected, the hierarchically porous carbon materials with a regulated structure with an appropriate pore volume, broadened pore-size distribution, ultrahigh specific surface area, as well as the effective hetratom dopping manifested its remarkable capacitor performances. The highest specific capacitance for a porous carbon material achieved was 557.9 F g-1 (at 1 A g-1) and 291.0 F g-1 (at 30 A g-1). The highest power density could reach up to 5679.62 W kg-1, and energy density achieved was 12.44 W h kg-1, thus greatly promoting its use in the design and synthesis of high-performance electrode materials for supercapacitors.

Rational Design and Engineering of One-Dimensional Hollow Nanostructures for Efficient Electrochemical Energy Storage.

The unique structural characteristics of one-dimensional (1D) hollow nanostructures result in intriguing physicochemical properties and wide applications, especially for electrochemical energy storage applications. In this Minireview, we give an overview of recent developments in the rational design and engineering of various kinds of 1D hollow nanostructures with well-designed architectures, structural/compositional complexity, controllable morphologies, and enhanced electrochemical properties for different kinds of electrochemical energy storage applications (i.e. lithium-ion batteries, sodium-ion batteries, lithium-sulfur batteries, lithium-selenium sulfur batteries, lithium metal anodes, metal-air batteries, supercapacitors). We conclude with prospects on some critical challenges and possible future research directions in this field. It is anticipated that further innovative studies on the structural and compositional design of functional 1D nanostructured electrodes for energy storage applications will be stimulated.